Functional Biotin Micelles for Targeted Drug Delivery

Micelles are molecularly ordered aggregates formed when the surfactant concentration reaches a certain value in aqueous solution. In micelles, the hydrophobic groups of surfactant molecules aggregate to form the inner core of the micelles, and the hydrophilic polar groups form the outer layers of the micelles. Thanks to the amphiphilic polymer micelle structure, hydrophobic drugs are soluble within the hydrophobic core, while the shell retains a hydration barrier that protects the integrity of each minicell. Micelles can serve as stable containers in physiological environments, enabling fine-tuned drug loading and targeted drug delivery. At present, a major problem facing cancer treatment is that anticancer drugs cannot distinguish cancer cells from normal cells. The outer layer of the micelles can be functionalized to detect the molecular signatures of cancer cells for efficient targeted therapy. Development of functionalized biotin micelles as drug carriers with active targeting capabilities for enhanced delivery efficiency of drugs and specific cancer treatments.

The Services

Micelles are efficient carriers of anticancer drugs and are one of the effective materials favored by researchers. The development of functional targeting biotin micelles as efficient drug carriers can improve the efficiency of drug delivery and enhance the efficiency of disease treatment. The researchers of Alfa Chemistry strive to expand the drug delivery system based on biotin micelles, and its related services include but not limited to:

• Synthesis of biotin micelles suitable for drug delivery
• Characterization of biotin micelles suitable for drug delivery
• Drug release studies
• Cell culture and in vitro experiments
• Stability test of biotin micelles
• Determination of the loading efficiency of biotin micelles
• Professional data analysis and comparison
• Preparation and characterization of copolymeric micelles

Characterization of biotin-modified micelles

• Biotin-modified micellar particle morphology
• Determination of particle size of biotin-modified micelles
• Stability of biotin-modified micelles
• Determination of drug loading efficiency in biotin-modified micelles

Targeted drug carrier based on biotin micelles

In order to improve the delivery efficiency of drugs, it is of great significance to develop active targeting drug carriers. Micelles can be targeted to specific sites of delivery by using the assembly of target molecules to target passively, size-dependently or actively. The carrier based on biotin micelles achieves a high degree of selectivity for specific organs to increase the degree of drug targeting.

Current research

More and more drug delivery systems are used for the treatment of cancer, which have tumor-targeting properties. Biotin-modified micelles can be used as containers for typical anticancer drugs (such as paclitaxel), and can be professionally designed to achieve targeted drug delivery and controlled release. Biotin-based functionalized micelles can be applied to drug delivery cases as follows:

1. Functionalized micelles for tumor-targeted delivery in vivo
2. Biotin-functionalized micelles actively targeting paclitaxel in cancer
3. Selective targeting of biotinylated micelles to the MCF-7 cancer cell line

The researchers of Alfa Chemistry focus on the use of biotin-modified micellar materials as containers for anticancer drugs, allowing the design of highly efficient drug delivery systems for a wide range of needs. If you are interested in our services, please contact us immediately.

References:

1. Hamed. N.; et al. Biotin-functionalized copolymeric PEG-PCL micelles for in vivo tumour-targeted delivery of artemisinin. H. NOSRATI et al. 2019, 47(1): 104-114.
2. Wang. Y.; et al. Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery. Journal of Controlled Release. 2020, 328(10): 970-984.
3. Anaëlle. D.; et al. Biotin-functionalized targeted polydiacetylene micelles. J. Name. 2012, 00: 1-3.

※ It should be noted that our service is only used for research, not for clinical use.