Monoclonal Antibody Delivery Based on Avidin-biotin System

Monoclonal antibodies can be used as replacement antibodies to restore, enhance, modify and mimic the immune system's attack on unwanted cells. Antibody drugs made of monoclonal antibodies are currently an effective way to treat many diseases. Monoclonal antibodies are antibodies that mimic your own immune system to have a unique effect on cancer cells. The avidin-biotin hormone enables the delivery of monoclonal antibody payloads to important targets of response. Avidin conjugation helps increase uptake at the target site. Avidin offers greater advantages in the field of drug delivery via monoclonal antibodies. Avidin fusion proteins engineered to be conjugated to monoclonal antibodies have shown excellent target specificity. In order to achieve high specificity for targeting molecules, the avidin-biotin system can be used for the delivery of monoclonal antibodies, which is still in the stage of rapid development.

The Services

Alfa Chemistry insists on providing customers with efficient avidin-biotin-related research, and the services it can provide include but are not limited to:

• Expression and purification of fusion protein
• In vitro characterization of monoclonal antibodies
• Immune reactivity/affinity of monoclonal antibodies
• Pharmacokinetics and biodistribution studies
• Monoclonal antibody customization service

Our service content and technical support

Alfa Chemistry provides a comprehensive solution that can complete the complete process from monoclonal antibody design, purification and detection. Our scientific researchers can choose the appropriate technology platform according to the target of interest and characteristics of customers. In addition, we also provide professional ELISA, WB, flow cytometry, IHC, cell-based screening, affinity detection and other characterization and screening techniques to ensure the most suitable monoclonal antibodies to meet the needs of research, diagnosis and treatment.

Custom service advantages of monoclonal antibodies

• Advanced antibody discovery technology: Professional processing technology and unique technical support
• Efficient antibody research and development platform: Rapid immunization, multiple purification methods
• Various antigen types: Recombinant protein, natural protein, insect virus, polypeptide
• Comprehensive detection platform: ELISA, WB, IHC, IF, FACS and ICC
• Customized solutions: According to the needs of customers, we can customize professional experimental solutions and perform efficient purification and screening
• Professional design: Experienced experts can support solutions from antigen design to development

Figure 2. Professional design platform, a wide range of sample types, to provide professional customized monoclonal antibody services

Related support

• Monoclonal antibody customization
• Polyclonal antibody customization

What can we provide?

Our custom monoclonal antibody service can handle all levels of complexity projects, whether it is simple or complex antigens requiring several or more monoclonal antibodies, and can support specific screening services. Our experts will do their best to satisfy customers' needs.

Service process

• Understand customer requirements for monoclonal antibodies
• According to the preparation needs of customers, a wide range of antigens can be provided
• Determine the preparation solution and communicate with technicians in detail
• Sign the agreement

Alfa Chemistry provides a comprehensive solution, we will cooperate with customers in an all-round way to complete the complete process from design, purification to detection. If you are interested in our services, please contact us immediately.

Reference:

1. Akshay. J.; et al. The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis. J Control Release. 2017, 10(245): 27-40.

※ It should be noted that our service is only used for research, not for clinical use.