Site-targeted Drug Delivery of Biotinylated Proteins

In biochemistry, biotinylation refers to the process of covalently attaching organisms to proteins, nucleic acids, or other biomolecules. Proteins are involved in functions such as assisting heredity, cell conduction, maintaining osmotic pressure and regulating human immunity, and are of great significance to the treatment of human health and diseases. Biotin is a naturally occurring metabolic enzyme cofactor that exhibits activity only when covalently attached to enzymes through the action of specific protein-biotin ligases. The binding of biotin to avidin is the strongest non-covalent interaction known in nature, so more and more high-affinity-based purification methods have been developed for protein purification. In recent years, protein biotinylation has been used in the field of efficient drug delivery. Based on the strong affinity, the delivery of high-efficiency drugs can be carried out at a fixed point, which is of great significance for the study of new drugs. Alfa Chemistry researchers are familiar with the characteristics of the biotin-avidin/streptavidin system, and can perform customized protein biotinylation according to customer needs, so as to develop an efficient site-specific drug delivery system.

The Services

Alfa Chemistry supports site-specific and efficient drug delivery based on protein biotinylation, including but not limited to:

• Plasmid construction
• In vivo biotinylation efficiency determination
• Detection of protein biotinylation degree
• Efficiency of protein biotinylation in vivo
• Design of specialized site-directed protein biotinylation drug delivery system

Protein biotinylation service advantages

Alfa Chemistry is committed to developing a variety of novel biotinylation strategies, and biotinylated proteins have been used in many applications, including IHC, IP, ELISA, flow cytometry, etc.

• Controllable application of biotinylation to specific sites for drug release
• Little effect on the functional domains of the protein
• The error between batches is small

What can we provide?

• Professional protein biotinylation platform
• Efficient and professional data analysis, support intelligent data comparison
• Rapid correlation-responsive protein biotinylation project
• Support global payments
• Broad range of protein biotinylation strategies

Prospects

With the development of biotechnology, more and more researchers are engaged in the research of applying protein biotinylation to efficient localized drug release. In the future, this technology will be combined with more micro-materials to make it fully biocompatible, and it is expected to be used for controllable targeted drug therapy to promote its efficient biomedical application. This type of technology provides a new solution for efficient local treatment and is expected to become a new type of treatment.

Alfa Chemistry provides services of biotinylated proteins adapted to a variety of samples for efficient targeted drug delivery, insisting on meeting customer needs. If you are interested in our services, please contact us immediately.

References:

1. Tsuneaki. A.; et al. A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted drug delivery. Biomolecular Engineering. 2005, 21(6): 145-155.

※ It should be noted that our service is only used for research, not for clinical use.