Biotin-Streptavidin Service

Streptavidin and avidin have similar biological properties and are both homotetrameric proteins. Streptavidin, a protein purified from the bacterium streptomyces avidin, has a high affinity for biotin. The binding of biotin to avidin is one of the strongest non-covalent interactions known in nature. Biotin-streptavidin has good tolerance to organic solvents, denaturants, detergents, proteolytic enzymes and pH, therefore, biotin-streptavidin can be widely used in molecular biology and biological in the field of nanotechnology. Based on the strong interaction between biotin and streptavidin, it can efficiently combine with biomolecules and realize the recognition of special molecules, so it is widely used in various biological fields. Alfa Chemistry has an advanced biotechnology team with many years of experience who can design highly efficient biotin-streptavidin systems for efficient biological applications. We are equipped with a precise quality control system, which can strictly control the quality of services, and carry out precise control throughout the process to meet the needs of customers.

The Services

Alfa Chemistry has a professional team, with the advantage of high-quality services, it insists on providing professional biotin-streptavidin related services. Our researchers have many years of experience and are supported by a professional team to provide customers with efficient and accurate services. The related services we can provide include but are not limited to:

• Design and construction of biotin-streptavidin system
• Professional data and analysis
• Solution customization

Advantages of the biotin-streptavidin system

Based on the tetrameric conformation of streptavidin, it can selectively bind biotin molecules with high affinity. The main advantage of the biotin-streptavidin system is the high detection sensitivity. The biotin-streptavidin system is also versatile and can be combined with a variety of labels, which can be used in a wide range of immunoassays, such as cell surface labeling, fluorescent cell sorting, and fluorescence detection imaging.

• Abundant targeting sites that support signal amplification
• Supports a variety of targeted site couplings, enabling the coupling of a variety of biomolecules

How to choose a streptavidin conjugate?

There is a strong interaction between biotin and streptavidin, and streptavidin can be combined with a variety of dyes, which is helpful for target labeling and biological imaging. According to customers' application requirements, the performance requirements of biotin-streptavidin conjugates are different, so researchers need to comprehensively consider the selection of materials in the design process. The biotin-streptavidin system has a very high binding force and has a wide range of applications in the biological field. Alfa Chemistry adopts professional protein coupling technology to covalently link streptavidin to the surface of solid phase carrier, which can be used to efficiently bind biotinylated antibodies, nucleic acids, proteins and other biomolecules.

Figure 2. The biotin-streptavidin diagram system can be widely used in the biological field

Advantages and features

• Excellent biotin molecule binding ability
• Good stability
• Adaptable to a wide range of experimental conditions

Biotin-streptavidin conjugation system

The biotin-streptavidin-based system has a small molecular size and can bind to biologically active macromolecules. The biotin-streptavidin system has high specificity, rapidity and high anti-interference ability, so it is widely used.

Alfa Chemistry can provide professional biotin-streptavidin services to meet customers' needs. If you are interested in our services, please contact us immediately.

Reference:

1. Welson. W. S.; et al. Design of a bifunctional fusion protein for ovarian cancer drug delivery: Single-chain anti-CA125 core-streptavidin fusion protein. European Journal of Pharmaceutics and Biopharmaceutics. 2007,65(3): 398-405.

※ It should be noted that our service is only used for research, not for clinical use.

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