Biotin-PEG

Biotin-PEG (Polyethylene Glycol) conjugates are versatile and highly effective reagents used across various fields, including biotechnology, diagnostics, and drug delivery. Biotin-PEG reagents are designed to covalently attach biotin to a wide range of biomolecules, such as proteins, peptides, oligonucleotides, and small molecules, without compromising their biological activity. The PEGylation process introduces a flexible, hydrophilic spacer that reduces steric hindrance, enhances water solubility, and minimizes non-specific binding. These characteristics are particularly valuable in applications where the biomolecule's functionality must be preserved and optimized for in vivo use.

Explore our complete catalog of biotin-PEG products to find the right solution for your research needs.

Product List

Various Biotin-PEG Products

Biotin-PEG products are available in a range of molecular weights and functional groups to suit different applications. Alfa Chemistry offers a variety of Biotin-PEG products, including but not limited to the following:

• Biotin-PEG-NHS

Ideal for labeling amine-containing biomolecules, such as proteins and peptides, through stable amide bond formation.

• Biotin-PEG-MAL

Specifically designed for labeling thiol groups on cysteine residues, forming stable thioether bonds.

• Biotin-PEG-Azide

Compatible with Click Chemistry, allowing for rapid and specific labeling of alkyne-functionalized molecules.

• Biotin-PEG-Alkyne

Suitable for Click Chemistry applications, providing a straightforward method to label azide-functionalized biomolecules.

Figure 1. (a) Chemical structures of biotin-PEG(1k, 5k, 40k)-DPPEs. (b) Schematic representation of the CH3-SAM surface modified with biotin-PEG-DPPE and streptavidin binding^[1].

Key Features of Biotin-PEG

A. Enhanced Solubility - The PEG moiety significantly increases the solubility of biotinylated molecules in aqueous solutions, facilitating their use in various biological assays and experiments.

B. Reduced Immunogenicity - PEGylation decreases the immunogenicity of biotinylated compounds, making them more suitable for therapeutic applications.

C. Improved Stability - Biotin-PEG conjugates exhibit increased stability in biological environments, leading to longer circulation times and better performance in vivo.

D. Versatile Applications - Suitable for a broad range of applications, including protein purification, cell labeling, targeted drug delivery, and diagnostic assays.

E. Customizable Linker Length - Available in various PEG linker lengths, allowing fine-tuning of the distance between biotin and the target molecule for optimal performance.

Reference:

1. Teramura Y; et al. Influence of Molecular Weight of PEG Chain on Interaction between Streptavidin and Biotin-PEG-conjugated Phospholipids Studied with QCM-D. Acta Biomaterialia. 2016, 30: 135-143.

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