Biotin Polymer Materials for Targeted Drug Delivery

Targeted drug delivery systems aim to increase the efficacy and reduce the toxicity of effective therapies for the treatment of various diseases. An important goal of drug therapy is to increase drug availability at the site of action while minimizing exposure to its target. Nanopolymer materials have been successfully applied in multifunctional drug delivery systems, which can be used for efficient drug delivery. Nanopolymer materials can carry out efficient surface functional modification, which is realized by functionalizing the surface of the carrier with tissue recognition ligands. Through NMR, surface plasmon resonance, and transmission electron microscopy can be used to demonstrate the delivery and uptake of nanopolymers for tumor cells. Nanopolymers can achieve efficient control of drug delivery and slow release, so they are widely used in targeted drug delivery. Efficient surface functionalization of nanopolymers opens up possibilities for drug targeting strategies.

The Services

Alfa Chemistry researchers have been studying the delivery and release of drugs for a long time, and are committed to expanding materials suitable for drug delivery to meet the application of various complex systems. Biotin-modified polymer materials are typical drug containers, and drugs can be coupled through surface functional modification. The related services we can provide include but are not limited to:

• Preparation and synthesis of biotin-modified polymers for drug delivery
• Characterization of biotin-modified polymers for drug delivery
• Drug release study of biotin-modified polymers drug delivery System
• Loading efficiency test of biotin-modified polymer
• Professional data analysis and comparison

Biotin-modified polymers for drug delivery cases

• Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles
• Biotin-modified inulin-based polymer micelles
• Biotin-dendrimer conjugates target cancer cells
• Biotin-modified HPMA polymer micelles for targeted drug delivery
• Biotin-functionalized targeted polymer micelles

Surface-modified polymers for efficient drug delivery

Polymer materials have become multifunctional carrier systems that can deliver drugs to target tissues for efficient drug delivery and slow release to achieve efficient and sustained therapeutic effects. Polymers are typical drug-loaded containers, which can be used for efficient drug delivery by combining functional groups on drug-loaded polymers through functional modification of the surface. Surface functional modification allows a variety of functional ligands to be bound to the material in a targeted manner, providing a high possibility for efficient targeted drug delivery.

Characterization biotin-modified polymeric materials

• Fourier Transform Infrared Spectroscopy (FT-IR)
• X-ray Diffraction Analysis (XRD)
• Transmission Electron Microscopy (TEM)
• Scanning Electron Microscope (SEM)
• Atomic Force Microscopy (AFM)
• Raman Analysis
• Drug Loading and Release Effects
• Drug Encapsulation Efficiency
• Cell Viability Assay
• Adenosine Triphosphate (ATP) Assay
• Lactose Dehydrogenase (LDH) Assay

Alfa Chemistry researchers are committed to using polymers in the field of efficient drug delivery, developing a variety of suitable systems to meet customer needs. If you are interested in our services, please contact us immediately.

References:

1. Massoumeh. B.; et al. Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery. Journal of Polymer Research. 2014, 21: 567.
2. Delia. M.; et al. Design, synthesis and evaluation of biotin decorated inulin-based polymeric micelles as long-circulating nanocarriers for targeted drug delivery. Nanomedicine: Nanotechnology, Biology and Medicine. 2017, 13(3): 1245-1254.
3. Yang. W.J.; et al. Targeting cancer cells with biotin–dendrimer conjugates. European Journal of Medicinal Chemistry. 2009, 44(2): 862-868.
4. Wang. Y.; et al. Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery. Journal of Controlled Release. 2020, 328(10): 970-984.
5. Anaëlle. D.; et al. Biotin-functionalized targeted polydiacetylene micelles. Chem. Commun. 2018,54: 3613-3616.

※ It should be noted that our service is only used for research, not for clinical use.