Avidin-biotin System for Drug Delivery

The avidin-biotin interaction is one of the strongest covalent noncovalent interactions in nature. Avidin and its analogs are widely used in bioanalysis, medical diagnosis, affinity purification and drug delivery and other fields. Utilizing the strong interaction of avidin-biotin, it can be used in a wide range of nanoscale drug delivery systems, and is suitable for the efficient delivery of small molecules, proteins, vaccines, monoclonal antibodies and nucleic acids. Specific targeted drug delivery systems with biological activity are the main goals of biomedical research. The purpose of targeted delivery is to deliver drugs to target organs in a controlled manner. At present, more and more researchers pay attention to the avidin-biotin system and explore its application in the field of drug delivery. The avidin-biotin system can amplify weak signals, has high stability, and can run efficiently. The nanomaterials that have been developed so far have multi-armed nanomaterials, nanoparticle materials and chelates, etc., which can be used for the delivery of various drugs.

The Services

Alfa Chemistry can provide biotin-related services and develop a variety of avidin-biotin systems suitable for drug delivery to expand its wide range of applications. Related services we can provide include but are not limited to:

• Development of nanomaterials suitable for the avidin-biotin system
• Characterization of nanomaterials suitable for the avidin-biotin system
• Testing of drug loading efficiency
• Drug release testing and evaluation
• Cytotoxicity test
• Mechanism based tumor-targeted drug delivery dystem

The functional group of biotin is chemically modified to synthesize biotin

Biotin, consisting of a tetrahydrothiophene ring fused to a tetrahydroimidazolone (ureido) ring, plays a key role in cell signaling and acts as a cell growth promoter. The functional groups of biotin are chemically modified to synthesize biotin analogs such as iminobiotin, ethylbiotin, desthiobiotin, biotin-carbamate, and biotin-carbonate for various applications. Biotin receptors are ubiquitously expressed in almost all living cells, with higher expression in dividing cancer cells than in normal cells, making biotin a potential targeting moiety for cancer therapy.

Current research

The researchers are focusing more on developing a wide range of materials that can be applied to the drug delivery of the avidin-biotin system. The current research that researchers can provide involves the following materials:

• Avidin-biotin multi-armed nanomaterials
• Avidin-biotin nanoparticle material
• Avidin-biotin chelate

Mechanisms of avidin-based drug delivery systems

The interaction between avidin and biotin is the strongest known non-covalent interaction, which can be widely used in drug delivery systems. Specific targeting system with biological activity is an important direction of current biological research, which can meet the requirements of efficient drug delivery and release.

Figure 2. The avidin-biotin system can be used for efficient targeted drug delivery

Customization capabilities and advantages

• A professional R&D team with leading technology and rich experience, which can support the design of materials suitable for avidin-biotin system
• Perfect quality control system, strictly control the quality of materials
• Professional management system, control process optimization service
• Tailor-made custom production to help customers design suitable materials
• We provide efficient customization of various materials

The researchers of Alfa Chemistry strive to expand multifunctional materials suitable for the drug delivery field of avidin-biotin system. If you are interested in our services, please contact us immediately.

References:

1. Zhang, C.Z.; et al. Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery. MethodsX. 2020, 7: 100882.
2. Akshay. J.; et al. The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis. J Control Release. 2017, 10(245): 27-40.

※ It should be noted that our service is only used for research, not for clinical use.