Protein Biotinylation for Intravascular Drug Delivery

Endothelial cells (ECs) are involved in important physiological activities, including angiogenesis in atherosclerosis and cancer, and controlling ECs can greatly facilitate the treatment of diseases. Cellular proteins of endothelial cells are biotinylated and either bound by avidin or made into a linker to bind biotinylated drugs. At present, researchers combine protein biotinylation and drug treatment to deliver drugs in blood vessels, which can achieve efficient drug immobilization. Through intravascular protein biotinylation, an efficient drug delivery system can be designed, which can selectively deliver drugs to a limited area, and can reach various parts of the body through blood vessels. At present, the research on drug delivery based on protein biotinylation is in an emerging stage of development, with great potential and space for development. Alfa Chemistry researchers are committed to protein biotinylation for drug delivery and provide a wide range of strategies for intravascular drug delivery. Our researchers support accurate effect analysis and are capable of providing high-quality services to customers around the world.

The Services

Alfa Chemistry has a team of professional technicians who can provide customized protein biotinylation services according to customer needs. We insists on meeting customers' needs with high-quality services, and the services it can provide include but are not limited to:

• Design and upgrade of detection scheme
• Cell-bound biotin assay
• Time determination of the amount of bound biotin
• Determination of cell-bound biotin
• Measurement of avidin immobilized on biotinylated cells
• Intravascular biotinylation in vivo
• Determination of biotin in endothelium

About biotinylated proteins

In biochemistry, biotinylated protein is the covalent combination of biotin and protein and other macromolecules, which has the advantages of high affinity, high specificity and high sensitivity. The biotin-avidin system has been widely used in immunodiagnostic techniques.

Features and benefits of the biotinylation platform

Alfa Chemistry provides specialized protein biological services that can be used in efficient drug delivery systems. The biotinylated proteins we provide will be strictly tested to ensure that the activity of the protein will not be affected before and after biotinylation. With years of technical accumulation, our researchers optimize the process, strictly control the cost and quality, and provide customers with better protein biotinylation services. We provide a wide range of protein biotinylation strategies, covering most of the drug targets, and can provide fast and efficient biotinylation services for drug targets.

What can we provide?

• Professional protein biotinylation platform for efficient drug delivery
• Efficient protein biotinylation strategy for a variety of samples
• Professional data analysis to help customers analyze

Alfa Chemistry provides high-efficiency biotinylation protein services, and can perform efficient and rapid biotinylation services for drug targets according to customer requirements to meet customer needs. If you are interested in our services, please contact us immediately.

References:

1. Katsumi. H.; et al. A novel intravascular drug delivery method using endothelial biotinylation and avidin-biotin binding. Drug Delivery. 2001, 8: 215-222.

※ It should be noted that our service is only used for research, not for clinical use.