Mechanism Based Tumor-Targeted Drug Delivery System

Cancer is one of the serious diseases affecting human health at present, and it is of great significance to achieve efficient treatment for maintaining human health. Currently available cytotoxic chemotherapy drugs such as paclitaxel, cisplatin, and doxorubicin face the main problem of not being able to distinguish cancer cells from normal cells and may face the risk of systemic cytotoxicity. In summary, the development of tumor-specific drug delivery systems for anticancer agents that recognize both normal and tumor cells is an urgent need for effective cancer therapy. The tumor-targeted drug delivery system is directly coupled with the recognition part and the drug, and can exist stably in the blood entering the whole body and can be separated. Currently, a tumor-targeted drug delivery system based on the efficient mechanism of tumor-specific vitamin receptor-mediated endocytosis has been developed.

The Services

Alfa Chemistry offers the design of biotin-based drug delivery systems for efficient oncology drug delivery. Related studies we can provide include but are not limited to:

• Molecular probes of biotin-linker-drug conjugates
• Design of efficient tumor-to-drug delivery systems and molecular probes
• Design of efficient tumor drug delivery solutions
• Cytotoxicity assessment
• Professional data analysis and comparison
• Preparation of targeted nano drug delivery system

Current research

Tumor-targeted drug delivery is applicable to a variety of drug conjugates composed of a variety of tumor-targeting molecules, such as monoclonal antibodies, aptamers, vitamins, peptides, and proteins. At present, a highly efficient mechanism-based tumor-targeted drug delivery system has been successfully designed: a tumor-targeting molecule, a mechanism-based self-sacrificing linker and a second-generation paclitaxel conjugate cytotoxic agent. This conjugation system is used for overexpressed vitamin receptors on the surface of tumor cells, and efficient internalization via receptor-mediated endocytosis, followed by smooth drug release via glutathione-triggered linker self-immolation.

Figure 2. Schematic diagram of tumor-targeting drug conjugates, drug release, and drug binding to target proteins

What can we provide?

• Preparation and research of targeted nano drug delivery system
• Research on precursors of anticancer drugs
• Study on nano drug delivery system regulated by tumor microenvironment

Related scientific research platform

Alfa Chemistry has a professional laboratory to develop a new biotin research platform, which can expand its application in the field of tumor treatment. We have professional researchers and cooperate with world-leading teams to master advanced technologies and serve customers with a wide range of strategies.

Advantages of teamwork

• Advanced laboratory, equipped with advanced equipment and first-class research team
• The project team has independent research and development capabilities, rich experience and rich scientific research experience
• The project is developed in cooperation with enterprises, focusing on meeting the needs of customers

Alfa Chemistry provides specialized biotin systems for efficient drug delivery. If you are interested in our services, please contact us immediately.

Reference:

1. Chen. S.Y.; et al. Mechanism-based tumor-targeting drug delivery system. validation of efficient vitamin receptor-mediated endocytosis and drug release. Bioconjugate Chem. 2010, 21(5): 979-987.

※ It should be noted that our service is only used for research, not for clinical use.