Biotinylated Bilirubin Material for Targeted Drug Delivery

The tumor microenvironment (TME) plays a crucial role in tumorigenesis and cancer cell metastasis. Drug delivery systems (DDS) that are targeted and responsive to the tumor microenvironment will produce highly effective antitumor efficacy. Excess reactive oxygen species (ROS) are produced in most tumors, such as tumor-associated macrophages, inflammatory cells, and myeloid-derived suppressor cells. Due to the elevated reactive oxygen species content in the tumor microenvironment, the drug delivery system will release the drug, thereby promoting the internalization of the drug in cancer cells and resulting in more efficient tumor efficacy. Currently, researchers have developed a cancer-targeted drug delivery carrier that can be used as targeted drug delivery. Bilirubin-based nanoparticles were used as drug delivery vehicles, enabling ROS-responsive drug release. Doxorubicin (Dox) is a typical cancer treatment drug, which can be efficiently attached to the carrier to form a Dox@bt-BRNPs system, which can be delivered to the site of tumor occurrence. This drug delivery system can accelerate the release of doxorubicin and exhibit high anticancer activity on HeLa cells, showing great potential.

The Services

Doxorubicin is a highly effective drug for the treatment of cancer, and more and more researches focus on loading doxorubicin on highly efficient carriers to achieve efficient drug delivery. Alfa Chemistry has experienced experts who can provide customers with professional services. Related services that can be provided include but are not limited to:

• Drug packaging
• Preparation of biotin-functionalized bilirubin nanoparticles
• Drug load detection
• Measurement of intracellular ROS
• Drug activity test

Tumor microenvironment

Tumor microenvironment (TME) refers to the surrounding microenvironment where tumor cells exist, including surrounding blood vessels, immune cells, myeloid-derived inflammatory cells, fibroblasts and various signaling molecules. Tumors are closely related to and interact with their surrounding environment, which can promote tumor angiogenesis and induce immune tolerance by releasing cell signaling molecules to affect its microenvironment. The common cell characteristics in the tumor microenvironment are as follows: the number of T cells with cytotoxic function decreases; the number of suppressor cells and regulatory T cells increases; macrophages and neutrophils are respectively composed of pro-inflammatory M1 and N1 The phenotype changes to the M2 and N2 phenotypes that suppress the immune response and promote tumor growth.

Bilirubin

Bilirubin (BR), an endogenous bile pigment and the final metabolite in the heme catabolic pathway, has antioxidant and immunomodulatory properties. Bilirubin is an important basis for judging jaundice clinically, and it is also an important indicator of liver function. Bilirubin-based nanoparticles have been found to have strong therapeutic effects on a variety of diseases, and have attracted much attention in the medical field. Studies have found that bilirubin-based nanomaterials have a certain response to light or reactive oxygen species (ROS), so they can be used as effective drug carriers for drug delivery, showing great potential in the field of medical treatment.

Alfa Chemistry has a professional team with many years of experience in the development and design of drug delivery systems, and can design reasonable services for customers to meet their needs. If you are interested in our services, please contact us immediately.

Reference:

1. Yong. H. L.; et al. Biotinylated bilirubin nanoparticles as a tumor microenvironment-responsive drug delivery system for targeted cancer therapy. Adv. Sci. 2018, 18000177 (1-8).

※ It should be noted that our service is only used for research, not for clinical use.