Vaccine Delivery Based on Avidin-biotin System

A vaccine is a biological product that provides effective acquired immunity against a specific infectious disease. Vaccines can be made of bacteria, viruses, tumor cells and metabolites, which can make the body produce specific immunity. In recent years, there has been interest in the development of vaccines. Significant efforts have been made to shorten the time between discovery and clinical development of selected vaccines. Currently, the biggest challenge for vaccine development is to generate the appropriate amount of antigen in vivo to induce an optimal immune response. Vaccine stability is the most important aspect in the vaccine development process, and the need to develop vaccines with high stability is of great significance for current research. Currently, more and more studies are focused on expressing avidin fusion protein and target protein to achieve stable and efficient antigen expression. The vaccine development process also faces the challenge of the extended time required to achieve effective in vivo concentrations of the immunogen. The use of avidin in recombinant vectors increases the possibility of delivering a variety of biotinylated antigens.

The Services

Alfa Chemistry provides professional vaccine research solutions and insists on meeting customers' needs with high-quality services. Our vaccine delivery services based on avidin-biotin include but not limited to:

• Design of vaccine delivery solution based on avidin-biotin system
• Visual characterization of specific B cells

Vaccine research considerations

• Neutralize infection (prophylactic vaccine)
• Neutralizes signaling molecules (e.g. tumor-associated growth factors)
• binding ability cell surface receptor
• The ability of antibodies

Our service commitment

• Standardized operation of monoclonal antibody service process
• Provide timely information on experimental progress according to customer needs
• Customer information and project information strictly follow the confidentiality system

Alfa Chemistry offers a wide range of vaccine delivery services based on the avidin-biotin system. If you are interested in our services, please contact us immediately.

References:

1. Zhang, C.Z.; et al. Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery. MethodsX. 2020, 7: 100882.
2. Antonio. S.; et al. Fast track selection of immunogens for novel vaccines through visualisation of the early onset of the B-cell response. Vaccine. 2005, 23: 1900-1909.

※ It should be noted that our service is only used for research, not for clinical use.