Biotin Conjugates for Targeted Drug Delivery

Biotin is a typical small molecule, which plays an important role in biochemical reaction pathways such as fat synthesis, gluconeogenesis, and aspartic acid. The activated biotin is cross-linked with the primary amine on the antibody or protein to form a stable amide bond to realize the coupling reaction between biotin and antibody or protein. Targeted drug delivery is an important challenge project in the current medical field. The development of novel targeted drug delivery systems that can overcome drug resistance and side effects is of great significance for improving therapeutic efficacy. Biotin can be used as a targeting ligand to improve tumor-specific cellular uptake. Biotin molecules and biotin conjugates can be preferentially absorbed by cancer cells, so biotin conjugate systems and drugs can be combined for efficient drug delivery. Alfa Chemistry has an advanced biological team that provides customers with a variety of targeted drug delivery systems based on biotin coupling, focusing on the detection of targeted drug delivery efficiency to meet further needs of customers.

The Services

Alfa Chemistry's researchers focus on the design and development of various biotin-conjugated drug delivery systems, insisting on meeting customer needs, and its related services include but are not limited to:

• Design and development of biotin-based targeted drug delivery system
• Biotin-based targeted drug delivery system solution
• Cytotoxicity test of experimental samples
• In vivo drug release from experimental samples
• Drug encapsulation efficiency test

Current research

Biotin is a typical small molecule, which can be easily coupled with other biomolecules, and can be used as an efficient drug carrier to enhance the effect of biological therapy. Cancer is one of the most serious diseases, seriously affecting human health. Biotin-based conjugation systems can be modified to enhance drug delivery efficiency and therapeutic efficiency for multifunctional and efficient cancer therapy. Extensive research has been focused on this area:

1. The researchers successfully developed the design and synthesis of a gemcitabine-coumarin-biotin conjugate system, a cancer-targeting theranostics DDS containing a GMC-loaded coumarin moiety that is conjugated to biotin as the target to the ligand. Its excellent performance can be demonstrated through spectroscopic characterization and in vitro biological evaluation. This drug delivery system is a new theranostics, in which the therapeutic effect and drug uptake can be easily monitored at the subcellular level by two-photon fluorescence imaging.

Figure 2. The gemcitabine-coumarin-biotin conjugate system is a targeted cancer theranostics

2. Biotin is an essential micronutrient for cellular function, and its receptors are overexpressed in some cancers, allowing targeted drug delivery for therapeutic purposes. The researchers synthesized the dendritic polymer polyamidoamine (PAMAM) and paclitaxel (PTX) for coupling, which can precisely deliver drugs for efficient anticancer.

Figure 3. G4 PAMA dendrimer system for specific delivery of paclitaxel (PTX) to cancer cells for highly effective therapy

In the future, more research will focus on more precise control of drug delivery to treat cancer with precision, efficiency and controllability, providing an important direction for the subsequent development of drug delivery systems.

What can we provide?

• Professional solution
• Efficient data analysis and comparison
• Precise design of biotin-conjugated drug delivery system

Based on the high efficiency of the biotin-coupled system, Alfa Chemistry strives to expand its application in the field of targeted therapy. If you are interested in our services, please contact us immediately.

References:

1. Sukhendu. M.; et al. Gemcitabine-coumarin-biotin conjugates: a target specific theranostic anticancer prodrug. J. Am. Chem. Soc. 2013, 135(11): 4567-4572.
2. Bidyut. K.; et al. Cancer-targeted chitosan-biotin-conjugated mesoporous silica nanoparticles as carriers of zinc complexes to achieve enhanced chemotherapy in vitro and in vivo. 2022, 5 (1): 190-204.
3. Rompicharla. S.V.K.; et al. Biotin functionalized PEGylated poly(amidoamine) dendrimer conjugate for active targeting of paclitaxel in cancer. International Journal of Pharmaceutics. 2019, 557(25): 329-341.

※ It should be noted that our service is only used for research, not for clinical use.