Streptavidin Fusion Proteins and Drug Delivery in Ovarian Cancer

Ovarian cancer is one of the most common malignant tumors affecting women's health, usually occurs in the peritoneal cavity, and eventually leads to death. Although surgery or chemotherapy has been widely used in clinical research and experiments, the treatment effect on most patients is not good, and the mortality rate is still very high. Pre-targeted radioimmunotherapy of scFv-streptavidin fusion proteins has been used in clinical research and is very promising as a therapeutic approach A smaller scFv-core-streptavidin fusion was developed Protein would be desirable. Biotinylation-based therapeutic materials or inhibitory materials may be an alternative approach to provide a variety of highly effective methods for the treatment of ovarian cancer. Alfa Chemistry researchers focus on efficient biotinylation strategies, design function-specific targeted treatments, and develop efficient therapeutic strategies to meet customer needs. In the future, our researchers will focus on the efficient treatment of cancer based on biotinylation for a long time, so as to be applicable to a wider range of therapeutic strategy applications and clinical trials.

The Services

The researchers of Alfa Chemistry are working on highly efficient biotinylation strategies to establish perfect targeting vectors for immunotherapy of ovarian cancer. The related services we provide include but are not limited to:

• Plasmid vector construction, expression and purification
• Western blot detection
• Affinity analysis
• Detection of protein biotinylation degree
• Development of efficient targeted therapy strategies

Liposomes as targeting carriers for cancer drugs

Liposome is a widely studied nano-drug carrier in current drug delivery system. It is a closed vesicle composed of a lipid bilayer composed of phospholipids and cholesterol. Liposome has a biomembrane-like structure and can encapsulate water-soluble and fat-soluble drugs. It has high selectivity, non-toxicity, non-immunogenicity, and is suitable for biodegradation. Liposomes have very low toxicity, can enhance antitumor efficacy, and can improve the therapeutic index of anticancer drugs. Liposomes can coat a variety of biotinylated therapeutic biomaterials, including biotinylated drugs, toxins, therapeutic proteins, biotinylated liposome-encapsulated vesicles, or biotinylated nanoparticles containing drugs or radioisotopes such as, can be used for the efficient treatment of ovarian cancer.

Efficient protein biotinylation features and advantages

• Fast, efficient and easy to operate
• Economical and cost-effective
• Global payments
• Broad range of protein biotinylation strategies

The researchers of Alfa Chemistry are dedicated to specialized biotinylation strategies and are working on developing a variety of materials suitable for coating biotinylated drugs for highly effective ovarian cancer treatment. In the future, our researchers will devote themselves to the research of new materials for a long time, which is expected to play an important role in the field of biotherapy. If you are interested in our services, please contact us immediately.

References:

1. Welson. W. S.; et al. Design of a bifunctional fusion protein for ovarian cancer drug delivery: Single-chain anti-CA125 core-streptavidin fusion protein. European Journal of Pharmaceutics and Biopharmaceutics. 2007,65(3): 398-405.

※ It should be noted that our service is only used for research, not for clinical use.