Selective Drug Delivery of Avidin-biotin System

The selective delivery of bioactive substances aims to overcome the nonspecific biodistribution of drugs and increase the local concentration of drugs in targeted tissues or organs. Selective delivery can deliver drugs, radioactive nucleic acids, genes, probes and small biomolecules to targeted tissues or organs. Loading drugs for treating diseases into biotinylated carriers can achieve efficient drug delivery. Targeted delivery of drugs helps to concentrate the concentration for efficient treatment. The selective delivery of the avidin-biotin system is mainly carrier-based delivery, which enables surface ligands or molecules on targeting cells to be delivered to target tissues and organs. The special site on the structure of avidin can bind biotin with high affinity, and the system has high stability to maintain long retention time. Efficient design of the avidin-biotin system can achieve highly concentrated drug release to specific tissues and organs to achieve efficient and selective drug delivery.

The Services

The specifically modified avidin-biotin system enables drug release to be concentrated in the target tissues and organs. At present, the researchers of Alfa Chemistry are focusing more on the design of selective drug targeting system, and the related services that can be provided include but are not limited to:

• Selective drug delivery of avidin-biotin
• Professional solution design
• Professional data comparison and analysis

Scalable platform features and benefits

• Support for specific labeling and modification
• Avidin-biotin system focuses drug release
• Specific target binding site

Selective targeted drug delivery based on avidin-biotin

The long-term stability of avidin shows great application potential in the field of targeted drug delivery. High-efficiency biotin-avidin can be used for the stable coupling of drugs and carriers. Selectivity is the degree to which a drug acts on a given site relative to other sites. The interaction between biotin and the reactive substance or drug and carrier induces a gradual and predominant tissue localization and release at the site of action. Controlled drug delivery and release applicable by modification based on avidin-biotin covalent conjugation.

How to improve the selectivity of drug delivery?

• According to the characteristics of the drug delivery system, the drug with relatively strong selectivity can be directly
• Some drugs are highly selective
• Design of targeted drug delivery system

What can we provide?

Alfa Chemistry's experts try their best to meet the needs of customers, whether it is the design of the avidin-biotin system, or the development and modification of the drug delivery system. Our researchers focus on improving the performance of selective drug delivery systems and expanding their applications in related fields to meet customer needs.

Our service advantages

• We guarantee on-time delivery
• Professional industry technical support, responsive project response
• Complete orders in a fast cycle

Alfa Chemistry provides a comprehensive avidin-biotin-based system, can provide comprehensive solutions, and can support the complete process services from design, purification and detection. If you are interested in our services, please contact us immediately.

Reference:

1. Limor. C.; et al. Tissue selective affinity targeting using the avidin-biotin system. DRUG DEVELOPMENT RESEARCH. 2000, 50: 258-271.

※ It should be noted that our service is only used for research, not for clinical use.