Construction of Biotin Targeted Drug Delivery System

Construction of Biotin Targeted Drug Delivery System

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Construction of Biotin Targeted Drug Delivery System

Construction of Biotin Targeted Drug Delivery System

Cancer is caused by uncontrolled cell growth, seriously affecting human health and causing high medical costs. Cancer is one of the serious diseases affecting human health at present, and the realization of efficient treatment is of great significance to the maintenance of human health. Currently applicable cytotoxic chemotherapy drugs include paclitaxel, cisplatin and doxorubicin. The problem faced by these drugs is that they cannot distinguish cancer cells from normal cells and may face the risk of systemic cytotoxicity. The effectiveness of cancer therapy depends largely on tumor-specific drug delivery efficiency. The content of biotin receptors in cancer cells is significantly increased, and biotin receptors and biotin can be efficiently combined to become a targeting ligand for cancer chemotherapy. The development of tumor-specific drug delivery systems that recognize both normal and tumor cells is an urgent need for effective cancer treatment. This targeted drug delivery system can efficiently recognize drugs and be coupled with biotin, and can exist and separate stably in blood, thereby realizing efficient targeted drug delivery.

The Services

Cancer is one of the important factors that seriously affect human health at present, and more and more methods are used for efficient drug delivery and professional tumor treatment. Alfa Chemistry researchers have many years of experience, focusing on the research of highly efficient targeted nano drug delivery systems, capable of controlled drug release, and committed to the research of single-target and dual-target drug delivery systems. The related services that our researchers can provide include but are not limited to:

In order to specifically target and eradicate cancer cells, it is necessary to precisely distinguish tumor cells from normal cells, and future nanomedicine may require new design principles to achieve active targeting of nanocarriers.

Dual-ligand is a new approach in which the drug delivery system has different ligands to target different receptors, which can be expressed in different cell types. The nano-drug delivery of dual ligands has attracted much attention because of its functionalization, which can greatly improve the therapeutic effect of tumor-targeted drug delivery.

The development of tumor-specific drug delivery systems that recognize anticancer agents in both normal and tumor cells is an urgent need to effectively treat cancer. The tumor-targeted drug delivery system is directly coupled with the recognition part and the drug, and can be stably present in the blood entering the whole body and can be separated.

Cooperation ability and advantages

  • Laboratory support: R&D team with many years of synthesis experience, equipped with advanced instruments, providing efficient synthesis customization services
  • Focus on research and development: We focus on technology research and development, have independent research and development capabilities, and have rich scientific research experience
  • Cooperation team: We have established a good cooperative relationship with the world's leading teams to meet the diverse needs of custom synthesis
  • Professionals: The rich experience in relevant knowledge, development and design of professional drug delivery systems

A professional team and high-quality partners can provide professional drug delivery system development and researchFigure 2. A professional team and high-quality partners can provide professional drug delivery system development and research

Expansion and renewal of specialized biological drug delivery systems

  • Support more reasonable strategies to realize gradual upgrade of the system
  • Scalable biotin-based targeted drug delivery platform

Targeted drug delivery

Targeted drug delivery refers to the delivery of drugs to a specific location through a carrier, and the lesion site becomes the target site. An efficient targeted drug delivery system needs elements such as positioning, concentration, controlled release, and non-toxicity. It has the characteristics of improving drug properties, safety, and effectiveness, and can reduce drug toxicity.

Alfa Chemistry has a professional laboratory, has independent research and development capabilities, has accumulated rich knowledge, and has the ability to provide customers with satisfactory targeted design and development. If you are interested in our services, please contact us immediately.

References:

  1. Welson. W. S.; et al. Design of a bifunctional fusion protein for ovarian cancer drug delivery: Single-chain anti-CA125 core-streptavidin fusion protein. European Journal of Pharmaceutics and Biopharmaceutics. 2007,65(3): 398-405.
  2. Chen. S.Y.; et al. Mechanism-based tumor-targeting drug delivery system. validation of efficient vitamin receptor-mediated endocytosis and drug release. Bioconjugate Chem. 2010, 21(5): 979-987.

※ It should be noted that our service is only used for research, not for clinical use.