Biotin Hybrid Materials for Targeted Drug Delivery

Hybrid materials are mixtures of two nano- or molecular-level components that exhibit new properties and show great potential for applications in the biomedical field. Common nanocarrier systems include liposomes, polymer micelles, chitosan, carbon nanotubes and nanoparticles, etc., which can improve the therapeutic effect of drugs and reduce drug toxicity. Doxorubicin (DOX) is one of the important drugs for the treatment of cancer, but its clinical application is limited due to its severe side effects (such as organ toxicity, alopecia or bone marrow suppression, etc.). Common targeting ligands include folic acid, transferrin, galactosamine, and biotin. Biotin can improve the targeting of the drug delivery system and is widely used in targeted drug delivery systems. Due to the overexpression of biotin receptors in cancer cells, researchers can apply biotin-modified hybrid nanomaterials to efficient drug delivery systems for efficient drug delivery and release.

The Services

Biotin-modified hybrid materials have the advantages of large specific surface area, good biocompatibility and degradability, and non-toxicity. Alfa Chemistry researchers focus on the use of biotin-modified hybrid materials in the field of drug delivery to expand their wide range of applications. Related services we can provide include but are not limited to:

• Surface functional modification of biotin-modified hybrid materials
• Preparation of biotin-modified hybrid materials
• Characterization of biotin-modified hybrid materials
• Professional data analysis and comparison
• In vitro drug release study of biotin modified hybrid materials
• Stability test of biotin-modified hybrid materials

Features and advantages of biotin hybrid materials

Compared with the hybrid material without biotin, the biotin-ligand-modified hybrid material exhibited stronger cytostatic and cellular uptake in tumor cells. Biotinylated hybrid materials have broad application prospects in the field of drug delivery. Biotinylated hybrid materials have the following advantages:

• Large specific surface area
• Large aperture
• Non-toxic
• Good biocompatibility
• Good biodegradability
• Controllable surface charge
• Functionalized surface modification

Biotin hybrid material

Nano-drug delivery systems enter cells through endocytosis, and drugs can be released from internalized nanomaterials. The surface of hybrid materials requires targeting ligands, and biotin receptors are highly expressed in cancer cells, which can realize the delivery and release of drugs in fixed organs throughout the body. Biotin hybrid materials combine two or more nanomaterials to deliver multiple drugs together, overcome multidrug resistance in cancer chemotherapy, and show broad application prospects in the field of cancer treatment. Hybrid materials can introduce desirable properties through surface functionalization for easy drug encapsulation, providing a multifunctional platform for cancer therapy.

Alfa Chemistry researchers use biotinylated hybrid materials in a broad range of drug delivery systems. If you are interested in our services, please contact us immediately.

Reference:

1. Wu. J. L.; et al. Biotinylated carboxymethyl chitosan/CaCO₃ hybrid nanoparticles for targeted drug delivery to overcome tumor drug resistance. RSC Adv. 2016, 6: 69083-69093.

※ It should be noted that our service is only used for research, not for clinical use.