Biotin Magnetic Molecularly Imprinted Polymers for Targeted Drug Delivery

Molecularly imprinted polymers have been developed based on mimicking the molecular recognition of antibodies and antigens. Molecularly imprinted polymer is a kind of polymer material, which has high affinity and specific molecular recognition ability, high stability, easy preparation and low cost. In recent years, with the development of biomedicine, more and more high-performance materials have been widely used in research, and molecularly imprinted polymers are a typical one. The development of molecularly imprinted polymers for tumor therapy has become a new research direction, showing great application potential in specific targeted therapy. One of the problems currently faced by molecularly imprinted polymers for drug delivery is the lack of precision and targeting. Molecularly imprinted polymers are still in the rapid development stage. The efficient modification of biotin on molecularly imprinted polymers can promote the targeting in the process of drug delivery and release, which provides a new direction for the current disease treatment.

The Services

Alfa Chemistry researchers are committed to expanding the application of molecularly imprinted polymers in the field of drug delivery, and the related services they can provide include but are not limited to:

• Design and development of biotin-modified molecularly imprinted polymers
• Characterization of biotin-modified molecularly imprinted polymers
• Drug release testing of efficient drug delivery systems
• Cytotoxicity assay
• Professional data analysis and comparison
• Stability test

Features and benefits of molecularly imprinted polymers for drug delivery systems

Molecularly imprinted polymer materials can regulate cell signaling pathways, and molecularly imprinted polymers have shown great application potential in the field of specific targeting, providing a broader strategy for achieving efficient drug therapy. Molecularly imprinted polymers will exhibit the following characteristics in the field of targeted drug delivery:

• Prolonged circulation time: Molecularly imprinted polymer materials can be modified to inhibit phagocytosis, prolong circulation time in vivo and increase tumor accumulation. More and more researches are focused on the development of new molecularly imprinted polymer materials to prolong the circulation time in vivo and enhance the ability of targeted drug delivery.
• Actively targeting tumor cells: On the surface of tumor cells, specific receptor proteins or abnormal post-translationally modified sugar chains are overexpressed, which can be used as ideal targets. Molecularly imprinted polymers can perform specific recognition and can achieve efficient tumor cell targeting.
• Controlled drug release: Molecularly imprinted polymers are developed based on mimicking the molecular recognition of antibodies and antigens, therefore, drug loading can be performed in the imprinted cavities. In the process of drug release, the interaction between the imprinted cavity and the drug can respond to the external environmental changes, so as to achieve controllable drug release, improve the therapeutic effect and reduce the toxicity of the drug.
• Multifunctionality: Molecularly imprinted polymers enable more effective cancer therapy by integrating different functions. Bifunctional molecularly imprinted polymers are used for drug delivery, which can simultaneously combine targeting molecules and release drugs, and more recognition sites and drug loading points make targeted drug delivery more efficient.

Figure 2. Molecularly imprinted polymers can be widely used in targeted drug delivery systems

What can we provide?

• Function-oriented design of molecularly imprinted polymer drug delivery system
• Professional design and characterization services

Future development

In the future, more biotin-modified molecularly imprinted polymers will be developed for drug delivery. Despite the major challenges, biotin-modified molecularly imprinted polymers have opened up new research avenues, and will develop in a more precise, more efficient, broader, and more ideal direction, showing great application potential.

Alfa Chemistry aims to develop a variety of molecularly imprinted polymers to provide a wide range of strategies in the field of drug therapy. If you are interested in our services, please contact us immediately.

Reference:

1. Maria. N.; et al. Biotinylated magnetic molecularly imprinted polymer nanoparticles for cancer cell targeting and controlled drug delivery. Chem. Commun. 2022, 58: 5642-5645.

※ It should be noted that our service is only used for research, not for clinical use.