Other Labeling Reagents

Biotinylation reagents are critical tools in molecular biology, biochemistry, and diagnostic research, allowing for the specific and targeted modification of molecules such as proteins, nucleic acids, and other biomolecules. Each reagent in this category is designed to provide specific functionalities, enabling researchers to tailor their labeling strategies to their unique experimental needs. Whether for the preparation of diagnostic assays, the creation of affinity tags, or the synthesis of complex biotinylated molecules, these reagents are indispensable tools in modern biological research.

Explore our complete catalog of other Labeling Reagents to find the right solution for your research needs.

Product List

Categories include but are not limited to:

• Methyltetrazine-activated Biotinylation Reagents

Methyltetrazine-activated biotinylation reagents are designed for bioorthogonal labeling, providing high specificity and efficiency in biotin conjugation. The tetrazine moiety reacts with trans-cyclooctene (TCO)-modified molecules in a fast, selective click reaction, ensuring minimal off-target effects. These reagents are ideal for labeling biomolecules in complex biological systems where maintaining the integrity of the native structure is crucial.

• Biotin Alcohol

Biotin alcohols serve as versatile intermediates in the synthesis of biotinylated derivatives. Their hydroxyl group can be further modified or activated for conjugation with various biomolecules, making them essential in creating custom biotinylation strategies. These reagents are especially useful in developing affinity tags for protein purification and detection assays.

• Biotin-PEG-Bromide

Biotin-PEG-bromide reagents are valuable for introducing biotin into molecules via a polyethylene glycol (PEG) spacer, enhancing solubility and reducing steric hindrance. The bromide group facilitates nucleophilic substitution reactions, allowing for the efficient attachment of biotin to amines or other nucleophiles. This approach is particularly beneficial in labeling sensitive biomolecules where direct biotinylation might impair function.

• Biotin-Iodide

Biotin-iodide reagents are key for introducing biotin into molecules through halogen exchange or nucleophilic substitution reactions. The iodide group provides a more reactive leaving group compared to bromide, allowing for quicker and more efficient biotinylation. These reagents are often used in solid-phase synthesis and in the preparation of biotinylated probes for imaging and diagnostic applications.

• Biotin-NHBoc

Biotin-NHBoc (tert-butyloxycarbonyl) is a protected form of biotin, used as an intermediate in multi-step syntheses. The Boc group protects the amine functionality during reactions and can be removed under mild acidic conditions to yield the free amine, ready for conjugation. This reagent is essential for creating complex biotinylated molecules where selective protection and deprotection steps are required.

• Biotin-Methyl Ester

Biotin-methyl ester is a biotin derivative where the carboxyl group is esterified with methanol. This esterification temporarily masks the carboxyl group, allowing selective modifications to occur at other reactive sites. The methyl ester can be hydrolyzed back to the free acid under mild conditions, making it a versatile reagent in the synthesis of biotinylated compounds.

• Biotin-PEG-Lipoamide

Biotin-PEG-lipoamide combines the biotin molecule with a lipoamide group via a polyethylene glycol (PEG) linker. This reagent is particularly useful in creating biotinylated probes that target enzymes or other proteins with lipoic acid-binding sites. The PEG spacer ensures flexibility and reduces steric hindrance, enhancing the interaction between the biotinylated probe and its target.

• Fluorescein Biotin

Fluorescein biotin conjugates combine the high-affinity binding properties of biotin with the fluorescent signal of fluorescein. This dual functionality allows for the simultaneous detection and purification of biomolecules. Fluorescein biotin is widely used in fluorescence microscopy, flow cytometry, and other imaging techniques where visualizing the biotinylated target is essential.

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