Biotin Modification Service

Biotin is a small molecular growth factor widely distributed in animals and plants, also known as coenzyme R or vitamin H, which is insoluble in water but easily soluble in dimethylformamide. Biotin can be tightly combined with avidin or streptavidin to form a biotin-avidin system (BAS). Biotin has the characteristics of rapidity, good specificity and high stability, and can perform multi-level amplification of signals, and can be widely used in the fields of immunodiagnosis, biomedicine and protein labeling. Biotin labeling and modification have the advantages of high affinity and multi-stage amplification, and can be combined with a variety of immunological techniques, such as luciferin, enzymes or isotopes, and have become one of the important tools in modern biological research. Biotin labeling and modification show the advantages of being more stable, more accurate and more convenient, and can be widely used in a variety of detection systems.

The Services

Biotin can be closely and specifically combined with chicken albumin, avidin, mycoprotein, and streptavidin, so as to achieve functional modification and expand its application to a wide range of uses. Related services we can provide include but are not limited to:

• Biotin efficient modification service
• Solution customization

Advantages and features of biotin

Biotin is a small molecular growth factor widely distributed in animals and plants. It can bind tightly and specifically with avidin or co-avidin to form a new biological amplification system: biotin-avidin system . Biotin has the advantages of rapidity, good specificity and low molecular weight without affecting the natural function of the molecule. Labeling and modification of biotin can be used in immunoassays and labeling, protein labeling, molecular labeling, etc. Biotin labeling is more stable, accurate and convenient, and can be used in various detection systems, while also avoiding the harm caused by radioactive isotopes to the human body.

Service levels and capabilities

We cooperate with the world's leading companies. They have many years of accumulation in the field of compound synthesis and material improvement, and have done many successful samples for biotin labeling and modification. Our researchers focus on technological innovation, master leading technology, and can provide customers with efficient biotin-related services. Currently, researchers have successfully modified the following systems:

• Biotin-shikonin system
• Biotin-oryzanol system
• Biotin-nobiletin
• Biotin-artemisinin
• Biotin-chlorogenic acid

In the future, more biotin-modified systems will be developed, which have great potential in the fields of biological diagnosis and treatment.

Service tips

Amount of sample: In the process of establishing the biotin modification system, there may be essential consumption. When the amount of sample is too small, it will affect the success rate of the experiment.

Purity determination: In the process of biotin modification, it is necessary to detect the purity of the product before and after modification, so as to facilitate the statistics of efficiency.

Alfa Chemistry has focused on the custom synthesis industry for many years, and has many years of experience in biotin modification services to meet customer needs. If you are interested in our services, please contact us immediately.

Reference:

1. Welson. W. S.; et al. Design of a bifunctional fusion protein for ovarian cancer drug delivery: Single-chain anti-CA125 core-streptavidin fusion protein. European Journal of Pharmaceutics and Biopharmaceutics. 2007,65(3): 398-405.

※ It should be noted that our service is only used for research, not for clinical use.