Biotin is a typical small molecule, which has the characteristics of simple structure, few functional groups and small steric hindrance, and participates in the metabolism of carbohydrates, lipids and amino acids in cells. Overexpression of biotin receptors in cancer cells, biotin can be used as a targeting ligand to improve tumor-specific cellular uptake, so biotin receptors can be used as markers for cancer cells. Biotin-modified drug carriers can enhance targeting, aiming to improve therapeutic efficacy and reduce drug toxicity. The development of novel targeted drug delivery systems that can overcome drug resistance and side effects is of great significance for improving therapeutic efficacy. Biotin-functionalized materials are widely used in cancer-targeted drug and gene delivery systems, live cell imaging, biosensors or biotherapeutics. Alfa Chemistry has an advanced biological team that can provide customers with a variety of targeted drug delivery systems based on biotin modification, focusing on efficient targeted drug delivery.
Alfa Chemistry can develop and design high-quality biomaterials and modify them efficiently so that they can be widely used in the field of drug delivery. Our scientific researchers insist on meeting the needs of customers with high-quality services. The related services we can provide include but are not limited to:
There are van der Waals force and π-π stacking effect between graphene sheets, which can be used as an effective carrier to bind drugs, thereby performing coupling to achieve efficient drug delivery.
Due to the elevated reactive oxygen species content in the tumor microenvironment, the drug delivery system releases the drug, which promotes the internalization of the drug in cancer cells, resulting in more effective tumor efficacy.
Drug delivery systems based on nanomaterials and targeted multifunctional self-assembled materials can be used for efficient targeted therapy of cancer.
Biotin molecules and biotin conjugates can be preferentially taken up by cancer cells, so biotin conjugate systems and drugs can be combined for effective drug delivery.
Micelles can serve as stable containers in physiological environments, enabling fine-tuned drug loading and targeted drug delivery.
Nanopolymer materials have been successfully applied in multifunctional drug delivery systems and can be used for efficient drug delivery.
Cholesterol is widely distributed in the human body, so it can be used for oral, intravenous and transdermal administration with high efficiency.
Liposomes have a similar physiological mechanism to cell membranes, have good biocompatibility and safety, can encapsulate water-soluble and fat-soluble drugs, have high selectivity, non-toxicity, non-immunogenicity, and are suitable for biodegradation.
Chitosan is a biocompatible polymer with good biocompatibility and biodegradability, high-efficiency antibacterial and antioxidant activities, etc. Chitosan and its derivatives are widely used in disease treatment and medical fields.
Common nanocarrier systems include liposomes, polymer micelles, chitosan, carbon nanotubes, and nanoparticles, which can improve the therapeutic effect of drugs and reduce drug toxicity.
Molecularly imprinted polymers are a class of polymer materials with high affinity and specific molecular recognition capabilities, high stability, easy preparation, and low cost.
Biotin receptors are overexpressed in cancer cells, thus improving the targeting properties of drug delivery. In the field of biomedicine, drug carriers need to control the release of drugs, reduce drug toxicity, improve targeting performance and improve therapeutic effects. Through external stimuli, such as light, pH, temperature, magnetic field, oxidant, etc., the drug carrier can control and release the drug.
Figure 2. Efficient drug targeting system can effectively reduce drug toxicity and improve targeting to improve therapeutic effect
Alfa Chemistry can provide high-quality customized services to serve customers around the world. Our researchers have developed a variety of multifunctional biotin-modified materials and are committed to expanding their applications in the field of drug delivery.If you are interested in our services, please contact us immediately.
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