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The avidin-biotin interaction is one of the strongest non-covalent interactions in nature. Avidin and its analogs are therefore widely used as probes, biochemical analysis, diagnosis, affinity purification and drug delivery. The avidin-biotin system is used in the nano-delivery system of drugs, including small molecule drugs, small biological analysis, antibodies, proteins, vaccines, monoclonal antibodies and nucleic acids. Avidin can be combined with four biotins, which makes the system have high stability and is an important basis for a wide range of applications. The avidin-biotin system can be used to efficiently deliver a variety of biological small molecules, which can be used for drug delivery and diagnosis, and can be used for efficient disease treatment. Alfa Chemistry has a strict quality control system and has an experienced team that can provide customers with satisfactory services.
Alfa Chemistry provides a comprehensive avidin-biotin system, which can provide comprehensive solutions and support the efficient delivery of biomolecules, including drugs, nucleic acids, proteins, antibodies, vaccines and small molecules. In addition, our researchers can support the performance improvement of the existing delivery system, and the related services we can provide include but are not limited to:
Utilizing the strong interaction of avidin-biotin, it can be used in a wide range of nanoscale drug delivery systems, and is suitable for the efficient delivery of small molecules, proteins, vaccines, monoclonal antibodies and nucleic acids.
Nucleic acids, including plasmid DNA, siRNA, miRNA, aptamers, and oligonucleotides, are widely used as therapeutic agents for a variety of diseases. The negative charge and poor stability of nucleic acid are important factors affecting the function of nucleic acid. Based on the excellent pharmacokinetic properties of avidin, after in vivo administration, the drug-loading system will be internalized to achieve targeted drug delivery at specific sites.
Peptides and proteins are easily deformed, resulting in reduced activity. Therefore, the reduced activity caused by deformation should be avoided during the delivery of proteins and peptides. Due to the ease of biotinylation of proteins or peptides, avidin can be used to modify highly efficient delivery vehicles.
Vaccines are biological products that provide effective acquired immunity against specific infectious diseases. Vaccines can be made from bacteria, viruses, tumor cells and their metabolites, which can make the body produce specific immunity.
Monoclonal antibodies can be used as surrogate antibodies to restore, enhance, modify and mimic the immune system's attack on unwanted cells. The avidin-biotin hormone enables the delivery of monoclonal antibody payloads to important reactive targets.
Efficient delivery of small biomolecules is highly specific to the target site and can be achieved through the attachment of receptor-specific ligands. Avidin can allow multiple ligands to be modified on the surface, so as to achieve highly specific targeting, and can be used as a good bridge for specific receptor biodiagnosis.
The selective delivery of bioactive substances aims to overcome the nonspecific biodistribution of drugs and increase the local concentration of drugs in target tissues or organs. Selective delivery can deliver drugs, radioactive nucleic acids, genes, probes, and small biomolecules to target tissues or organs.
Biotin (Biotin, B) is widely distributed in animal and plant tissues, and its molecular weight is small (244.31). Biotin is easy to modify and can be a derivative with a variety of active groups. Activated biotin can couple to many biological macromolecules, including proteins, nucleic acids, polysaccharides and lipids. Avidin (avidin, AV), also known as avidin. When avidin and biotin are combined, the stability is significantly increased. The interaction between biotin and avidin is the highest known non-covalent interaction (K=1015 mol/L), which has high stability and is not affected by concentration, pH and environment. Each avidin can bind four biotins, which can amplify the signal. The avidin-biotin system can be used for quantitative and qualitative detection and localization observation of trace antigens, antibodies and receptors.
Figure 2. Schematic diagram of the avidin-biotin system
Figure 3. The professional avidin-biotin system can be used for the delivery of biomolecules, which has the advantages of high sensitivity, specificity, stability and universality
Alfa Chemistry has a professional laboratory, has independent research and development capabilities, has accumulated rich knowledge, and has the ability to provide customers with satisfactory services. If you are interested in our services, please contact us immediately.
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※ It should be noted that our service is only used for research, not for clinical use.
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