Desthiobiotin-PEG3-NHS Ester

Desthiobiotin-PEG3-NHS Ester

Catalog	BR00028498
CAS	2411681-92-8
Structure
Description	Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Synonyms	Desthiobiotin-PEG3-NHS ester
IUPAC Name	2,5-dioxopyrrolidin-1-yl 19-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)-14-oxo-4,7,10-trioxa-13-azanonadecanoate
Molecular Weight	514.58 g/mol
Molecular Formula	C23H38N4O9
Canonical SMILES	O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCNC(CCCCC[C@@H]2[C@H](C)NC(N2)=O)=O
InChI	InChI=1S/C23H38N4O9/c1-17-18(26-23(32)25-17)5-3-2-4-6-19(28)24-10-12-34-14-16-35-15-13-33-11-9-22(31)36-27-20(29)7-8-21(27)30/h17-18H,2-16H2,1H3,(H,24,28)(H2,25,26,32)/t17-,18+/m0/s1
InChI Key	JWHMGEZINQQWSX-ZWKOTPCHSA-N
Purity	≥98%
Solubility	Water, DMSO, DCM, DMF
Appearance	To be determined
Shelf Life	>2 years if stored properly
Storage	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Drug Formulation	To be determined
Elemental Analysis	C, 53.69; H, 7.44; N, 10.89; O, 27.98
Exact Mass	514.2639
HS Tariff Code	2934.99.9001
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage	0 - 4 C for short term (days to weeks), or -20 C for long term (months).

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