DBCO-PEG4-Desthiobiotin

DBCO-PEG4-Desthiobiotin

Catalog	BR00028443
CAS	2032788-37-5
Structure
Description	DBCO-PEG4-Desthiobiotin is a PEG linker containing a desthiobiotin group and a DBCO functional group. Desthiobiotin is used for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins while DBCO is a click chemistry handle that quickly reacts with azide groups on target molecules. Desthiobiotin is a sulfur-free analogue of biotin which binds streptavidin with slightly less strength than biotin, which provides it with a soft-release characteristic that is useful for in pull-down assays by minimizing co-elution with endogenous biotinylated molecules. The inclusion of a PEG linker in this molecule improves its aqueous solubility.
Synonyms	DBCO-PEG4-Desthiobiotin
IUPAC Name	N-(3-((Z)-dibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl)-1-(6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamido)-3,6,9,12-tetraoxapentadecan-15-amide
Molecular Weight	719.88 g/mol
Molecular Formula	C39H53N5O8
Canonical SMILES	O=C(CCCCC[C@@H]1[C@H](C)NC(N1)=O)NCCOCCOCCOCCOCCC(NCCC(N(CC2=C(C#C3)C=CC=C2)C4=C3C=CC=C4)=O)=O
InChI	InChI=1S/C39H53N5O8/c1-30-34(43-39(48)42-30)12-3-2-4-14-36(45)41-20-22-50-24-26-52-28-27-51-25-23-49-21-18-37(46)40-19-17-38(47)44-29-33-11-6-5-9-31(33)15-16-32-10-7-8-13-35(32)44/h5-11,13,30,34H,2-4,12,14,17-29H2,1H3,(H,40,46)(H,41,45)(H2,42,43,48)/t30-,34+/m0/s1
InChI Key	RLLRLVMWDMAIJT-BFGHFXMOSA-N
Purity	≥95%
Appearance	Solid powder
Shelf Life	>3 years if stored properly
Storage	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Drug Formulation	This drug may be formulated in DMSO
Elemental Analysis	C, 65.07; H, 7.42; N, 9.73; O, 17.78
Exact Mass	719.3894
HS Tariff Code	2934.99.03.00
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage	0 - 4 C for short term (days to weeks), or -20 C for long term (months).

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