Biotin hydrazide

Biotin hydrazide

Catalog	BR00028430
CAS	66640-86-6
Structure
Description	Biotin hydrazide is a biotinyl derivative that can be used as a probe for the determination of protein carbonylation, which is a component of several diseases. Protein carbonylation, an irreversible post translational modification (PTM), is caused by attack of reactive oxygen species (ROS), numerous lipid oxidation products (such as α,β-unsaturated γ-hydroxyalkenals), or nonemzymatic glycation resulting in the loss of protein function. Biotin hydrazide is a preferred carbonyl-reactive probe for its direct reaction and chemistry and no requirement of additional catalysts or reducing agents. Biotin hydrazide exclusively and readily derivatizes carbonyl groups at pH 5.5, which facilitates its use to measure carbonylated proteins in biological samples.
Synonyms	(+)-Biotin Hydrazide; Biotin-Hz; Hydrazide Biotin; Biotine Hydrazide
IUPAC Name	5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanehydrazide
Molecular Weight	258.3 g/mol
Molecular Formula	C10H18N4O2S
Canonical SMILES	C1C2C(C(S1)CCCCC(=O)NN)NC(=O)N2
InChI Key	KOZWHQPRAOJMBN-ZKWXMUAHSA-N
Boiling Point	633.1ºC at 760 mmHg
Melting Point	245-247ºC
Flash Point	336.7ºC
Purity	0.98
Density	1.243 g/cm³
Appearance	white or slightly yellow powder
Storage	Store at -20°C
Exact Mass	258.11500
Shipping	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.

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